September 19, 2024
20/09/2024
September 19, 2024
Press release courtesy of Cell Press, with light edits for stylistic purposes.
LA JOLLA, CA A new international collaborative study from scientists at Scripps Research, the University of Arizona, the French National Centre for Scientific Research (CNRS), and others provides a list of the wildlife species present at the market from which SARS-CoV-2, the virus responsible for the COVID-19 pandemic, most likely arose in late 2019. The study is based on a new analysis of metatranscriptomic data released by the Chinese Center for Disease Control and Prevention (CDC). The data come from more than 800 samples collected in and around the Huanan Seafood Wholesale market beginning on January 1, 2020, and from viral genomes reported from early COVID-19 patients. The research appears September 19 in the journal Cell.
This is one of the most important datasets that exists on the origin of the COVID-19 pandemic, says co-corresponding author Florence D barre, PhD, of CNRS. We're extremely grateful that the data exist and were shared.
This paper adds another layer to the accumulating evidence that all points to the same scenario: that infected animals were introduced into the market in mid- to late November 2019, which sparked the pandemic, says co-corresponding author Kristian Andersen, PhD, professor in the Department of Immunology and Microbiology at Scripps Research.
We have analyzed, in new and rigorous ways, the vitally important data that the Chinese CDC team collected, says co-corresponding author Michael Worobey, DPhil, of the University of Arizona. This is an authoritative analysis of that data and how it fits in with the rest of the huge body of evidence we have about how the pandemic started.
On January 1, 2020, after the animals were removed and just hours after the market was closed, investigators from the Chinese CDC went to the market to collect samples. They swabbed the floors, walls, and other surfaces of the stalls; they came back days later to focus on surfaces in stalls selling wildlife, such as a cage and carts used to move animals, and then also collected samples from the drains and sewers.
They performed metatranscriptomic sequencing of the samples, a technique aiming to obtain all RNA sequences (and which can pick up DNA as well) from all organisms present in the samples viruses, bacteria, plants, animals, humans. The Chinese CDC team, led by Liu Jun, published their data and results in 2023 in the journal Nature. However, the article left unresolved the exact identities of the animal species found in the data that could represent plausible intermediate hosts. The Chinese CDC shared their sequencing data on public and open repositories.
According to the latest analysis of these data being published in Cell, SARS-CoV-2 was present in some of the same stalls as wildlife sold at the market including raccoon dogs (small fox-like animals with markings similar to raccoons) and civet cats (small carnivorous mammals related to mongooses and hyenas). In some cases, genetic material from the SARS-CoV-2 virus and these animals was even found on the same swabs. The exact animal species were identified by genotyping their mitochondrial genomes in the samples.
Many of the key animal species had been cleared out before the Chinese CDC teams arrived, so we can't have direct proof that the animals were infected, D barre says. We are seeing the DNA and RNA ghosts of these animals in the environmental samples, and some are in stalls where SARS-CoV-2 was found too. This is what you would expect under a scenario in which there were infected animals in the market.
These are the same sorts of animals that we know facilitated the original SARS coronavirus jumping into humans in 2002, Worobey adds. This is the most risky thing we can do take wild animals that are teeming with viruses and then play with fire by bringing them into contact with humans living in the heart of big cities, whose population densities make it easy for these viruses to take hold.
The international team also performed evolutionary analysis of the earliest viral genomes reported in the pandemic, including these environmental sequences, and inferred the most likely progenitor genotypes of the virus that infected humans and led to the COVID-19 pandemic. The results imply that there were very few, if any, humans infected prior to the market outbreak. This is consistent with spillovers from animals to humans within the market. There may also have been spillovers of limited impact in the immediate upstream animal trade.
In this paper, we show that the sequences linked to the market are consistent with a market emergence, D barre says. The main diversity of SARS-CoV-2 was in the market from the very beginning.
The new study landed on a short list of animal species in the wet market found co-occurring or close to viral samples that could represent the most likely intermediate hosts for SARS-CoV-2. The common raccoon dog, a species susceptible to SARS-CoV-2 and that carried SARS-CoV in 2003, was found to be the most genetically abundant animal in the samples from market wildlife stalls. Genetic material from masked palm civets, which were also associated with the earlier outbreak of SARS-CoV, was also found in a stall with SARS-CoV-2 RNA. Other species such as the Hoary bamboo rat and Malayan porcupines were also found to be present in SARS-CoV-2-positive samples, as well as a multitude of other species.
While the data cannot prove whether one or more of these animals may have been infected, the team's analyses provide a clear list of the spec
LINK: | https://www.scripps.edu/news-and-events/press-room/2024/20270919-ander... |
See more stories from scripps |
Most recent headlines
09/12/2024
Dalet Named an IDC Innovator in Media and Entertainment
Dalet, a leading technology and service provider for media-rich organizations, today announced that it has been named an IDC Innovator in the IDC Innovators: ...
09/11/2024
Dalet Expands Leadership Team to Fuel Next Stage of Growth
Dalet, a leading technology and service provider for media-rich organizations, today announced three new members of its executive team. Tara Bryant joins as Chi...
20/09/2024
Give Me the Backstory: Get to Know Alessandra Lacorazza, the Writer-Director Behind In The Summers
by Bailey Pennick One of the most exciting things about the Sundance Film Festi...
20/09/2024
Join Author Bella Mackie on a Musical Journey Inspired by Her Darkly Comic' New Book
As many readers will attest, wit and humor make for excellent counterparts to th...
20/09/2024
Partnering To Combat the Spread of Violent Content Online
At Spotify, our Platform Rules strictly prohibit content that promotes terrorism or violent extremism. We take action on content that violates our Platform Rule...
20/09/2024
Celebrate Latin Heritage Month With These Powerful Audiobooks
Latin culture has made an impact far beyond its geographical boundaries. The rich traditions and vibrant lifestyles have had a tremendous influence on the world...
20/09/2024
Optocore M8 MADI solves problems of clocking and rack space on Jason Aldean tour
events Youre reading: Optocore M8 MADI solves problems of clocking and rack space on Jason Aldean tour Innovative rig provides economical fiber transmis...
20/09/2024
L3Harris Chair and CEO Christopher E. Kubasik Speaks On CNBC's "Closing Bell: Overtime"
L3Harris Chair and CEO Christopher E. Kubasik sat down with CNBC to discuss what...
20/09/2024
Electronic Warfare Key to Indo-Pacific Power Projection Under AUKUS Framework
L3Harris CORVUS open, agile multi-role electronic warfare architecture....
20/09/2024
Charter Awards $1.3M in 2024 Spectrum Digital Education Grants
STAMFORD, Conn. Charter Communications, Inc. has awarded $1.3 million in grants to 66 nonprofit organizations through its 2024 Spectrum Digital Education progra...
20/09/2024
CVP announces second Education Festival
The free event for students and educational leaders will feature over 70 workshops, seminars and demonstrations By Matthew Corrigan Published: September 20, ...
20/09/2024
Meet the lead engineer
Jayne Hilton, Lead Engineer at Globecast, explains the importance of communication and openness to TVBEurope By Matthew Corrigan Published: September 20, 202...
20/09/2024
AJA Previews Virtual KONA in Collaboration with AWS at IB...
AJA today announced a preview of Virtual KONA, a new software-defined, virtualized video capture/playback solution that the company is developing in collaborati...
20/09/2024
Rise Announces Award Shortlist for 2024
Rise, the gender diversity network for the media technology industry, today announced the shortlist for the Rise Awards, which will take place on Tuesday Novemb...
20/09/2024
Double Award Success at IBC2024 for nxtedition
nxtedition is proud to announce its remarkable success at IBC2024, having been recognised with two industry awards. The company received the IABM BaM Award in t...
20/09/2024
CVP Announces the 2nd Annual Education Festival
CVP, one of Europe's leading resellers and providers of professional video and broadcast solutions, has announced that the Education Festival will return fo...
20/09/2024
Agile Content and Convergenze partner to launch Convergen...
Agile Content joins forces with Convergenze to introduce a new platform in Italy, offering a wide range of premium content for all audiences. Agile Content, a ...
20/09/2024
APL appoints JAM TV and EMG-Gravity Media as new Producti...
The Australian Professional Leagues (APL) has appointed leading sports production company JAM TV and global media services and facilities provider EMG/Gravity M...
20/09/2024
Appear releases latency reduction capabilities of up to 7...
Appear, the leader in media processing and delivery technology, today announced a significant update to its HEVC and AVC compression solutions at IBC 2024 (Hall...
20/09/2024
Ateme Deploys New Video Delivery Solutions with NVIDIA Ho...
Ateme, a global leader in video delivery solutions, is proud to announce it is deploying its Titan video processing and compression solution with NVIDIA Holosca...
20/09/2024
db group announces major update to SustainSymphony platfo...
d&b group announces the latest update to its SustainSymphony platform, a cloud-based sustainability management software designed for the live event industry. Th...
20/09/2024
BCE Expands its Custom Consoles Module-R and MediaWall at...
Custom Consoles announces the completion of a significant expansion to the Network Operation Centre control desk at the headquarters of Broadcasting Center Euro...
20/09/2024
VisionTV Goes Mobile: Modernizing Live Event Broadcasting with Blackmagic Design
VisionTV Goes Mobile: Modernizing Live Event Broadcasting with Blackmagic Design Brie Clayton September 19, 2024 0 Comments Australia's VisionTV b...
20/09/2024
Hollyland Launches the Solidcom SE Wireless Intercom System for Seamless Team Talk
Hollyland Launches the Solidcom SE Wireless Intercom System for Seamless Team Ta...
20/09/2024
Chaos' New Short Has an Answer for Hollywood VFX Problems
Chaos' New Short Has an Answer for Hollywood VFX Problems Brie Clayton September 19, 2024 0 Comments Emerging Virtual Production Tools Get First M...
20/09/2024
Daniel Alegre Appointed as CEO of TelevisaUnivision
TelevisaUnivision, Inc. has announced the appointment of Daniel Alegre as the company's new CEO effective September 19, 2024....
20/09/2024
WNBA on ION More than Doubles Viewers
New data from Scripps Sports provides fresh evidence of a rapidly growing interest in women's sports, with average viewership for the State Farm WNBA Friday...
20/09/2024
Mediacom Taps OpenVault for Improved QoE
MEDIACOM PARK, N.Y. & JERSEY CITY, N.J. OpenVault has announced that Mediacom Communications is using OpenVault's Profile Management Application (PMA) techn...
20/09/2024
Ateme Deploys New Video Delivery Solutions with NVIDIA Holoscan for Media
PARIS Ateme has announced that it is deploying its Titan video processing and compression solution with NVIDIA Holoscan for Media, an AI-enabled, software-defin...
20/09/2024
What's Next in Media Storage? Ensuring Reliability and Accessibility in Today's Busy Media Age
What's Next in Media Storage? Ensuring Reliability and Accessibility in Toda...
20/09/2024
SEG Media Launches New DTC Streaming Service for Utah Hockey Club In Partnership With Kiswe
SEG Media Launches New DTC Streaming Service for Utah Hockey Club In Partnership...
20/09/2024
The Underdogs: The CW Is Emerging as a Sports Destination With College Football
The Underdogs: The CW Is Emerging as a Sports Destination With College Football Partnered by Raycom Sports and Pac-12 Studios, The CW carries big-time ACC, Pac-...
20/09/2024
Rohde & Schwarz demonstrates advanced C-UAS capabilities at NATO TIE 2024
Rohde & Schwarz demonstrates advanced C-UAS capabilities at NATO TIE 2024 Rohde & Schwarz successfully showcases its ARDRONIS family at the NATO Technical Int...
20/09/2024
Hellbound' Resurrects: Season 2 Launch Trailer Unveils October 25 Premiere
Back to All News Hellbound' Resurrects: Season 2 Launch Trailer Unveils October 25 PremierePlay Video Play Video Entertainment 20 September 2024 Globa...
20/09/2024
Netflix Unveils Blood Line: A Rebel Moon Game' and More at Geeked Week 2024
Back to All News Netflix Unveils Blood Line: A Rebel Moon Game' and More at Geeked Week 2024 Entertainment 20 September 2024 Global Link copied to cli...
20/09/2024
Geeked Week 2024 Culminates With First-Ever Live In-Person Event
Back to All News Geeked Week 2024 Culminates With First-Ever Live In-Person Event Cobra Kai stars Jacob Bertrand and Xolo Maridue a with show host Joe Mangani...
20/09/2024
Medical Centers Tap AI, Federated Learning for Better Cancer Detection
A committee of experts from top U.S. medical centers and research institutes is harnessing NVIDIA-powered federated learning to evaluate the impact of federated...
20/09/2024
RT Radio 1 launches Drivetime In-Depth, a new series and podcast with Sarah McInerney and Cormac hEadhra
Drivetime In-Depth: War in Gaza podcast will chronicle the year's events fro...
20/09/2024
Immerse yourself in Culture Night 2024 as RT brings unmissable performances and celebrations to screens this Friday night
RT Celebrates Culture Night this Friday September 20, broadcasting on RT One a...
20/09/2024
September 19, 2024
Genetic tracing at the Huanan Seafood market further supports COVID animal origins An international collaboration between Scripps Research, University of Arizon...
19/09/2024
UKTV crowns the Classic Car Kings in new restoration series for U&YESTERDAY
UKTV has commissioned the new series, Classic Car Kings (6x60'), for leading factual channel U&YESTERDAY and free streaming service, U. The six-part series ...
19/09/2024
Visit ToolsOnAir at NAB New York 2024 Javits Center, October 9-10, 2024
Visit ToolsOnAir at NAB New York 2024 Javits Center, October 9-10, 2024 The ToolsOnAir team is excited to meet you again in person at NAB New York 2024 at ...
19/09/2024
Writer-Director Jennifer Kent on the 10th Anniversary of The Babadook and Horror as an Independent Art Form
Writer-director Jennifer Kent's The Babadook is returning to the big scree...
19/09/2024
Blue Lucy to demo asset portal and host FAST roundtable at MIPCOM 2024
Blue Lucy is bringing its new media portal, BOLT to MIPCOM 2024, Cannes, October 21-24th. On stand P-1.C50A at the MIPCOM Innovation Lab 2024, the team will de...
19/09/2024
Bottle Yard Studios sale can proceed
The sale will ensure the studios continues to achieve its potential into the future, said the council By Matthew Corrigan Published: September 19, 2024 Upd...
19/09/2024
Saankhya Labs, Sinclair To Collaborate on D2M ATSC 3.0 Devices
BENGALURU & DEHLI, India & BALTIMORE, Md. The long-awaited dream of Next-Gen TV reception on mobile phones took a big step forward today with the joint announce...
19/09/2024
DirecTV, Chicago Sports Network Reach Multi Year Distribution Agreement
CHICAGO & EL SEGUNDO, Calif. Chicago Sports Network (CHSN) and DirecTV announced a multiyear distribution agreement to provide the network and its live local ga...
19/09/2024
Spectrum Reach Becomes a Local Reseller for Amazon Ads
NEW YORK Spectrum Reach, the advertising sales business of Charter Communications, has announced a new multi-year agreement with Amazon Ads that will make Spect...
19/09/2024
SEC Taps Hawk-Eye Video Review Technology for Soccer, Volleyball
BIRMINGHAM, Ala. The Southeastern Conference is reporting that it will be using a multi-sport video review system supplied by Hawk-Eye Innovations, which is par...
19/09/2024
Rise Announces Award Shortlist for 2024
LONDON Rise, the gender diversity network for the media technology industry, has announced the shortlist for the Rise Awards, which will take place on Tuesday N...