COVID-19 patient antibodies point researchers toward broad coronavirus vaccines Certain antibodies isolated from people who had recovered from COVID-19 and were vaccinated have the ability to neutralize variety of coronaviruses.
June 02, 2022
LA JOLLA, CA Scientists at Scripps Research have characterized 30 antibodies that recognize a wide range of coronaviruses successfully blocking not only all the SARS-CoV-2 variants that were tested, but other, related viruses including SARS-CoV-1, which caused the original SARS outbreak with high mortality in 2003, one found only in bats and another from pangolins. The antibodies were all isolated from people with hybrid immunity who had been infected with SARS-CoV-2 and subsequently vaccinated against the virus.
The new details on the antibodies, published today in Nature Immunology, are a step toward the next generation of coronavirus vaccines, which may help ward off a broader swath of viruses than the current vaccines specific to SARS-CoV-2.
It's very encouraging that despite SARS-CoV-2 mutating, there are still parts of the virus you can target for broad vaccination strategies, says senior author Raiees Andrabi, PhD, an investigator in the Department of Immunology and Microbiology.
At the same time researchers work to develop new treatments and vaccines for the ongoing COVID-19 pandemic, many are also hoping to prevent the next pandemic. Coronaviruses a broad group of viruses which also cause some common colds have been responsible for COVID-19 as well as previous outbreaks caused by SARS-CoV-1 and Middle East Respiratory Syndrome (MERS) virus. A vaccine that helps the immune system recognize not only many SARS-CoV-2 variants, but other SARS-causing coronaviruses, could stop these viruses from spreading throughout the population.
In the new study, Andrabi and his colleagues compared antibody responses elicited in 21 people who had recovered from COVID-19, 10 people who had been vaccinated against COVID-19, and 15 with hybrid immunity from both. People with hybrid immunity showed the strongest and broadest spectrum of antibodies, able to neutralize or block five variants of SARS-CoV-2 (Alpha, Beta, Gamma, Delta and Omicron), SARS-CoV-1, as well as a pangolin coronavirus and one from horseshoe bats in China. No antibodies from the vaccination-only or infection-only group could neutralize all the viruses.
The team isolated 107 antibodies from two hybrid immunity donors, screening for molecules that could bind to both SARS-CoV-1 and SARS-CoV-2 spike proteins. Then, they homed in on 30 of those antibodies, many of which also neutralized the bat and pangolin coronaviruses for a closer look.
Most of those 30 antibodies, they found, recognized the same part of the viruses' structures, called the receptor-binding domain on the spike protein. Certain segments of the receptor-binding domain, the finding suggested, were not changing as different coronaviruses evolved. The 30 antibodies also had similarities when it came to how they were produced by the body, an important clue for researchers in how to design vaccines that prompt the immune system to produce the same antibodies.
To show that the antibodies did not just bind to the viruses in the lab, but could actually impact the immune system's ability to fight each pathogen, Andrabi's group, in collaboration with co-senior authors Ralph Baric and Lisa Gralinski at the University of North Carolina at Chapel Hill, observed what happened when mice treated with three of the most potent antibodies known as CC25.36, CC25.53 and CC25.54 were exposed to SARS-CoV-2, SARS-CoV-1, or the horseshoe bat virus SHC014-CoV. For all three viruses, the mice that had been treated with the antibodies had significantly lower levels of virus in their lungs compared to control mice.
We saw amazing protection against these three viruses, says Andrabi. That tells us that if we are able to induce these antibodies by vaccination, they will likely give you broad protection against diverse SARS-like viruses.
Now that we know these antibodies work, the next goal is to design vaccines and to try to elicit similar broadly-neutralizing antibodies by vaccination in approaches that have been pioneered at Scripps Research for HIV, says Dennis Burton, PhD, co-senior-author and chair of the Department of Immunology and Microbiology.
In addition to Andrabi, authors of the study, Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses, include Wan-ting He, Rami Musharrafieh, Ge Song, Katharina Dueker, Sean Callaghan, Peter Yong, Nathan Beutler, Jonathan Torres, Reid Volk, Panpan Zhou, Meng Yuan, Hejun Liu, Fabio Anzanello, Tazio Capozzola, Mara Parren, Elijah Garcia, Ian Wilson, Andrew Ward, Thomas Rogers, and Dennis Burton of Scripps Research; Long Ping Tse, David Martinez, Alexandra Schafer, Ralph Baric and Lisa Gralinski of the University of North Carolina at Chapel Hill; Stephen Rawlings and Davey Smith of University of California, San Diego; and Yana Safonova of Johns Hopkins University.
This work and the researchers involved were supported by funding from the National Institutes of Health (CHAVD UM1 AI44462 (D.R.B., I.A.W., A.D.B), the IAVI Neutralizing Antibody Center, the Bill & Melinda Gates Foundation (INV-004923), the Translational Virology Core of the San Diego Center for AIDS Research (CFAR) grant (NIH AI036214, 5T32AI007384, AI149644, AI157155, and R21 AI145372), the John and Mary Tu Foundation, the James B. Pendleton Charitable Trust, a Pfizer NCBiotech Distinguished Postdoctoral Fellowship in Gene Therapy, a Burroughs Wellcome Fund Postdoctoral Enrichment Program Award and a Hanna H. Gray Fellowship from the Howard Hughes Medical Institute.
COVID-19 Immunology & Microbiology Andrabi, Raiees
Most recent headlines
04/09/2025
Monumental Sports & Entertainment (MSE), in collaboration with Dalet, has been a...
23/04/2025
In 2024, Thomson's Total Turnout project played a pivotal role in elevating ethical election reporting and strengthening journalist safety in Pakistan.
Wit...
23/04/2025
We heard that you could use a little pick-me-up, so get ready to sh-sh-shake it ...
23/04/2025
WBD's Max viewership climbs 6%, boosted by The White Lotus' and The Pi...
23/04/2025
March shows a further downward trend of time spent watching television; following the February period when winter holidays contributed to a shorter time spent. ...
23/04/2025
During March, audiences in Mexico increased their streaming usage by 2.1 points compared to the previous month, accounting for 24.4% of TV viewing.
Disclaimer:...
23/04/2025
AANHPI audiences over index the total U.S. for share of time spent with Netflix ...
23/04/2025
SAN JOSE, Calif. Roku has announced new TVs, new streaming devices and significant upgrades to its user interface and software platforms that are designed to st...
23/04/2025
COW Job Listing: Opportunity for a Passionate Feature Film Editor - London-Based...
23/04/2025
RM Equity Partners Acquires MAGIX Software, Appoints Robert Rutkowski as CEO to ...
23/04/2025
All Men Are Wicked Western Shot with Blackmagic Design
Brie Clayton April 23, 2025
0 Comments
Blackmagic Pocket Cinema Camera 4Ks were put to the test...
23/04/2025
NEW YORK Warner Bros. Discovery captured the largest monthly viewership increase among media distributors in March, according to Nielsen's latest Media Dist...
23/04/2025
MIAMI, Fla. Hemisphere Media Group has inked a deal with Samsung to launch WAPA+ as a FAST channel on Samsung TV Plus, a free TV streaming service that comes pr...
23/04/2025
HEBDEN BRIDGE, U.K. Calrec Audio has promoted Sid Stanley to managing director. Stanley, who joined the company in July 2018 as general manager, has been instru...
23/04/2025
WASHINGTON Federal Communications Commission Commissioner Nathan A. Simington has announced a series of staff appointments made in March and April 2025, includi...
23/04/2025
WASHINGTON The Federal Communications Commission has set its agenda for the Monday, April 28, 2025 Open Meeting, which is scheduled to start at 10:30 a.m. in th...
23/04/2025
COW Job Listing: Full-Time Video Editor, Remote
Brie Clayton April 22, 2025
0 Comments
Full-Time Video Editor
April 23, 2025COW Job Listing: Opportu...
23/04/2025
Berklee Abu Dhabi's Jazz Night Kicks off Global Celebration of Music and Cul...
23/04/2025
The E.W. Scripps Co. said it was shutting down its Scripps News over-the-air channel effective November 15 and eliminating at least 200 jobs....
23/04/2025
Audio Helps Chess.com Checkmate Cheating Matches are produced using REMI workflows By Dan Daley, Audio Editor
Wednesday, April 23, 2025 - 7:00 am
Print Th...
23/04/2025
Tech Focus: Intercoms, Part 1 - Key to Onsite, REMI, Hybrid Operations Intercoms keep increasingly disparate production locations together By Dan Daley, Audio ...
23/04/2025
Speaking my language: Bringing AI to the fore with real time audio translation f...
23/04/2025
Back to All News
Netflix Drops Trailer for Crime Drama Secrets We Keep, Set in ...
23/04/2025
Back to All News
World Book Day: Netflix Announces New TV Adaptations and Impac...
23/04/2025
Comscore to Announce First Quarter 2025 Financial ResultsRESTON, VA, April 23, 2025 Comscore, Inc. (Nasdaq: SCOR), a trusted partner for planning, transacting...
23/04/2025
In an email to RT staff today, RT Director-General, Kevin Backhurst confirmed that RT 's Voluntary Exit Programme (VEP) 2025 is open from today, Wednesday...
23/04/2025
RT will air live coverage on television, radio and online of the funeral of Pope Francis which takes place this Saturday, 26 April 2025.
Beginning at 8.30am o...
23/04/2025
As AI models evolve and adoption grows, enterprises must perform a delicate balancing act to achieve maximum value.
That's because inference - the process ...
23/04/2025
Financial services has long been at the forefront of adopting technological innovations. Today, generative AI and agentic systems are redefining the industry, f...
23/04/2025
Facebook
Twitter
LinkedIn
Enables Michelin to focus on development of its ...
23/04/2025
AI is rapidly reshaping what's possible on a PC - whether for real-time image generation or voice-controlled workflows. As AI capabilities grow, so does the...
23/04/2025
An AI agent is only as accurate, relevant and timely as the data that powers it....
23/04/2025
April 23 2025, 02:00 (PDT) Dolby Ushers in the Future of In-car Entertainment at Auto Shanghai 2025
Dolby and industry partners demonstrate robust momentum ...
22/04/2025
Chloe Sevigny at the Magic Farm premiere (photo by Michael Hurcomb/Shutterstock for Sundance Film Festival)...
22/04/2025
Music has the power to connect us to one another and to the world around us. Spotify is once again teaming up with the Museum for the United Nations - UN Live&#...
22/04/2025
Spotify has an unwavering commitment to supporting emerging artists across all g...
22/04/2025
This year marks the 55th anniversary of Earth Day, celebrated annually on April 22. On Spotify, listeners can explore a world of stories about our planet in our...
22/04/2025
McAvaney takes the lead for SBS' Coverage of the World Athletics Championshi...
22/04/2025
Virtual idols are poised to revolutionize entertainment, with the market projected to top $4 billion by 2029. Crafted with motion capture and game engine techno...
22/04/2025
As the audiovisual (AV) industry rapidly evolves, educational institutions are preparing the next generation of AV professionals for the future. Singapore Polyt...
22/04/2025
DENVER A new survey highlights just how important streaming has become in the entertainment landscape. Data compiled by Adtaxi shows streaming isnt just an alte...
22/04/2025
Samsung TV Plus has announced that it is now offering nearly 700 streaming channels in the U.S. more than any of the other major FAST platforms, the streaming s...
22/04/2025
PORTSMOUTH, N.H. New findings from Hub Research's latest survey on sports and television coverage reveal Amazon may have cracked the code of how to use tech...
22/04/2025
DETROIT Rockbridge Growth Equity has sold a controlling stake in GSTV to MidOcean Partners. Rockbridge will retain a minority stake in the video network which i...
22/04/2025
ATLANTA Gray Media has promoted Dana Neves to senior managing vice president, overseeing a number of Gray's television markets in the Northeast and Mid-Atla...
22/04/2025
The Infrastructure of Creative Flow: DigitalGlue's creative.space Wins NAB 2...
22/04/2025
iZotope unveils Equinox: the ultimate reverb plugin for Post and Music productio...
22/04/2025
Every way to export transparent videos from After Effects
Graham Quince April 21, 2025
0 Comments
In this video, I break down each way you can export ...
22/04/2025
April 22nd, 2025 Press Materials Available Here
Tribeca Festival 2025 Announces Short Film Lineup
Featuring How I Learned to Die Executive Produced by Osca...
COVID-19 patient antibodies point researchers toward broad coronavirus vaccines Certain antibodies isolated from people who had recovered from COVID-19 and were vaccinated have the ability to neutralize variety of coronaviruses. 
